A tetrahydroacridine derivative and its conjugate with gold nanoparticles: promising agents for the treatment of Alzheimer's disease

A new tetrahydroacridine derivative (CHDA) with acetylcholinesterase inhibitory properties was synthesized. Using a range of physicochemical techniques, it was shown that the compound strongly adsorbs onto the surface of planar macroscopic or nanoparticulate gold, forming a nearly full monolayer. Th...

Full description

Saved in:
Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2023-06, Vol.25 (25), p.16796-1686
Main Authors: Mojzych, Ilona, Zawadzka, Anna, Kaczy ska, Katarzyna, Wojciechowski, Piotr, Zaj c, Dominika, Chotkowski, Maciej, Wiktorska, Katarzyna, Maurin, Jan K, Mazur, Maciej
Format: Article
Language:English
Subjects:
Alzheimer's disease
Conjugates
Conjugation
Electrochemical analysis
Gold
Health services
Medical imaging
Nanoparticles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new tetrahydroacridine derivative (CHDA) with acetylcholinesterase inhibitory properties was synthesized. Using a range of physicochemical techniques, it was shown that the compound strongly adsorbs onto the surface of planar macroscopic or nanoparticulate gold, forming a nearly full monolayer. The adsorbed CHDA molecules reveal well-defined electrochemical behavior, being irreversibly oxidized to electroactive species. The CHDA also exhibits strong fluorescence, which is effectively quenched after adsorption onto gold via a static quenching mechanism. Both CHDA and its conjugate reveal considerable inhibitory properties against acetylcholinesterase activity, which is promising from the perspective of therapeutic application in the treatment of Alzheimer's disease. Moreover, both agents appear to be non-toxic as demonstrated using in vitro studies. On the other hand, conjugation of CHDA with nanoradiogold particles (Au-198) offers new potential diagnostic perspectives in medical imaging. A new acetylcholinesterase inhibitor was synthesized. It has been demonstrated that both the compound itself and its conjugate with gold nanoparticles have potential applications in the treatment and diagnosis of Alzheimer's disease.
ISSN:1463-9076
1463-9084
DOI:10.1039/d3cp00767g