Microstructure, Corrosion, and Biological Responses of Mg-Al-Zn-Sr-xCa Alloys for Bioresorbable Applications

Mg-Al-Zn-Sr-Ca alloys with varying calcium content were prepared and examined for biomedical applications. Microstructural observations indicated grain refinement and increased second phase precipitation with increasing Ca content. Immersion test, potentiodynamic polarization study, and impedance sp...

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Bibliographic Details
Published in:JOM (1989) 2023-07, Vol.75 (7), p.2299-2313
Main Authors: Mandal, Tapendu, Dasgupta, Shalini, Barui, Ananya, Kundu, Sukumar
Format: Article
Language:English
Subjects:
Aluminum
Bacterial corrosion
Biocompatibility
Biomedical materials
Bones
Calcium
Calcium phosphates
Chemistry/Food Science
Corrosion rate
Corrosion resistance
Corrosion tests
Earth Sciences
Electrodes
Engineering
Environment
Grain refinement
Grain size
Human body
Immersion tests (corrosion)
Influence of Processing on Microstructure and Properties of Mg Alloys
Magnesium alloys
Magnesium base alloys
Mechanical properties
Microstructure
Neurotoxicity
Physics
Physiology
Strontium
Surgical anastomosis
Tissue engineering
Titanium alloys
Transplants & implants
Zinc
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Summary:Mg-Al-Zn-Sr-Ca alloys with varying calcium content were prepared and examined for biomedical applications. Microstructural observations indicated grain refinement and increased second phase precipitation with increasing Ca content. Immersion test, potentiodynamic polarization study, and impedance spectroscopy revealed that Ca content up to 1 wt.% improved the corrosion response of Mg-Al-Zn-Sr-Ca alloys studied in this work. Due to the combined effect of grain refinement, second phase precipitate barrier, and protective layer formation, the corrosion rate dropped from 1.84 mm/year in alloy Ca0.2 to 1.01 mm/year in alloy Ca1.0. Biocompatibility was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Ca1.0 showed the highest cell attachment and proliferation density. Ca formed Mg 2 Ca and improved the cell viability of the alloys.
ISSN:1047-4838
1543-1851
DOI:10.1007/s11837-022-05595-4