LC-Q-TOF-MS/MS detection of food flavonoids: principle, methodology, and applications

Flavonoids have been attracting increasing research interest because of their multiple health promoting effects. However, many flavonoids with similar structures are present in foods, often at low concentrations, which increases the difficulty of their separation and identification. Liquid chromatog...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023, Vol.63 (19), p.3750-3770
Main Authors: Yang, Minke, Li, Juan, Zhao, Chengying, Xiao, Hang, Fang, Xiang, Zheng, Jinkai
Format: Article
Language:English
Subjects:
Agricultural products
application
Data processing
detection
flavonoid
Flavonoids
Food
Food industry
Food processing
LC-Q-TOF-MS/MS
Liquid chromatography
Low concentrations
Mass spectrometry
Mass spectroscopy
Metabolism
methodology
principle
Principles
Quadrupoles
Qualitative analysis
Separation
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Summary:Flavonoids have been attracting increasing research interest because of their multiple health promoting effects. However, many flavonoids with similar structures are present in foods, often at low concentrations, which increases the difficulty of their separation and identification. Liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS) has become one of the most widely used techniques for flavonoid detection. LC-Q-TOF-MS/MS can achieve highly efficient separation by LC; it also provides structural information regarding flavonoids by Q-TOF-MS/MS. This review presents a comprehensive summary of the scientific principles and detailed methodologies (e.g., qualitative determination, quantitative determination, and data processing) of LC-Q-TOF-MS/MS specifically for food flavonoids. It also discusses the recent applications of LC-Q-TOF-MS/MS in determination of flavonoid types and contents in agricultural products, changes in their structures and contents during food processing, and metabolism in vivo after consumption. Moreover, it proposes necessary technological improvements and potential applications. This review would facilitate the scientific understanding of theory and technique of LC-Q-TOF-MS/MS for flavonoid detection, and promote its applications in food and health industry.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2021.1993128