Characterization of platelet concentrations and evaluation of risk factors for thrombocytopenia following traumatic injury

Introduction Thrombocytopenia is common in critically ill trauma patients and can lead to potentially broad differentials, including major bleeding, hemodilution, extracorporeal circuit losses, heparin-induced thrombocytopenia, and more. Understanding the normal time course of platelet decline and r...

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Bibliographic Details
Published in:Trauma (London, England) England), 2023-07, Vol.25 (3), p.243-248
Main Authors: Farrar, Julie E, Naik, Kushal, Van Matre, Edward T, Martin, Katelyn G, Magnotti, Louis J, Wood, G Christopher, Swanson, Joseph M
Format: Article
Language:English
Subjects:
Blood platelets
Circuits
Erythrocytes
Heparin
Injuries
Platelets
Risk factors
Thrombocytopenia
Trauma
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Summary:Introduction Thrombocytopenia is common in critically ill trauma patients and can lead to potentially broad differentials, including major bleeding, hemodilution, extracorporeal circuit losses, heparin-induced thrombocytopenia, and more. Understanding the normal time course of platelet decline and recovery may delineate thrombocytopenia(HIT) secondary to traumatic injury versus other inciting factors. Methods This retrospective study included trauma patients admitted over a 1-year period. The primary aim was characterizing the effect of trauma on platelet concentration and thrombocytopenia incidence in the first 30 days following injury. Thrombocytopenia was defined as platelet concentration
ISSN:1460-4086
1477-0350
DOI:10.1177/14604086221076280