Priapism on Chronic Myeloid Leukemia with BCR-ABL1 Fusion gene Identified by Molecular Test: A Case Report

The incidence of hematological malignancies has elevated in recent decades. Chronic Myeloid Leukemia (CML) is a hematopoietic stem cell malignant clonal disorder resulting in elevation of erythroid cells and platelets in peripheral blood and clear myeloid hyperplasia in the bone marrow. Priapism is...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2023-05, Vol.16 (5), p.2229-2232
Main Authors: Amalia, Yustisia, B. Notopuro, Paulus
Format: Article
Language:English
Subjects:
Blood platelets
Blood pressure
Bone marrow
Case reports
Emergency medical care
Erectile dysfunction
Genital diseases
Hematology
Hyperplasia
Hypertension
Kinases
Leukemia
Leukocytes
Oncology
Patients
Penis
Pregnancy
Proteins
Stem cells
Ultrasonic imaging
Urine
Womens health
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Summary:The incidence of hematological malignancies has elevated in recent decades. Chronic Myeloid Leukemia (CML) is a hematopoietic stem cell malignant clonal disorder resulting in elevation of erythroid cells and platelets in peripheral blood and clear myeloid hyperplasia in the bone marrow. Priapism is one of a rare clinical manifestation and serious complication in Chronic Myeloid Leukemia (CML). It is cause due to hematological disorder is most likely due to venous obstruction as well as hyperviscosity due to an increased number of circulating leukocytes mature and immature forms. We report a 30-year-old male came to the emergency room, presented with priapism caused by Chronic Myeloid Leukemia (CML) with hyperleukocytosis. The rarity of this case reiterates the importance of thorough morphological, cytogenetic examination along with radiology in diagnosing, treatment and follow up of patients. Starting leukemia therapy to reduce the leukocyte count immediately, can solve the problem in hyperleukocytosis that caused priapism in Chronic Myeloid Leukemia (CML).
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2023.00366