Partial Atrophy of The Pancreas in Endoscopic Ultrasonography may be a Sign of Pancreatic Cancer

• Published in: Istanbul medical journal 2023-05, Vol.24 (2), p.210-215
• Main Authors: Bakkaloğlu, Oğuz Kağan, Eşkazan, Tuğçe, Gültürk, İlkay, Yıldırım, Süleyman, Atay, Kadri, Kepil, Nuray, Erzin, Yusuf, Dobrucalı, Ahmet Merih
• Format: Article
• Language: English
• Subjects: Atrophy; Biopsy; cea; Cysts; Endoscopic ultrasonography; Endoscopy; fine needle aspiration biopsy; Medical prognosis; Medical research; Medicine, Experimental; mucinous pathology; Multivariate analysis; Pancreatic cancer; pancreatic carcinoma; Pancreatitis; Pathology; Regression analysis; Ultrasonic imaging; Veins & arteries
• ISSN: 2619-9793; 1304-8503; 2148-094X
• DOI: 10.4274/imj.galenos.2023.52386

Introduction: Solid and/or cystic lesions of the pancreas can range from benign to malignant, and the differential diagnosis of pancreatic carcinoma (PC) is of uttermost importance. Endoscopic ultrasonography (EUS) is frequently used and is helpful in detecting small (37 U/mL, and partial atrophy in the pancreas were independently associated with PC. For solid lesions, age and size >24 mm; and for cystic lesions, male gender and mucinous pathology were independently associated with PC. Thirty-six of the cystic lesions had mucinous pathology. Cyst and serum CEA, string sign, wesung connection, and tail location was associated with mucinous pathology. Cyst CEA cut-off for mucinous pathology was 80 ng/mL (AUC: 0.89). CEA >80 ng/mL was found to be associated with mucinous pathology in multivariate analysis. Conclusion: High CA19-9, solid lesion, and lesion-related partial atrophy of the pancreas are associated with PC, and these should be alarming for clinicians in practice. The mucinous character, which is a significant risk of PC for cystic lesions, can be optimally defined with the CEA cut-off value of 80 ng/mL.