Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats

Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administ...

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Bibliographic Details
Published in:Meandros medical and dental journal 2021-04, Vol.22 (1), p.53-56
Main Authors: Ceri, Nazli Gulriz, Gulle, Kanat, Arasli, Mehmet, Akpolat, Meryem, Demirci, Buket
Format: Article
Language:English
Subjects:
Acids
Animal models
Animals
Antioxidants
Apoptosis
Conflicts of interest
Diabetes
Diabetes mellitus
Ethics
Ischemia
Kidney diseases
Kidneys
Membranes
Metabolism
Nephropathy
Streptozocin
Tıp
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Summary:Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and Hematoxylin- Eosin stains. Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and longterm DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes. Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.
ISSN:2149-9063
2149-9063
DOI:10.4274/meandros.galenos.2021.65002