Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats

Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administ...

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Published in:Meandros medical and dental journal 2021-04, Vol.22 (1), p.53-56
Main Authors: Ceri, Nazli Gulriz, Gulle, Kanat, Arasli, Mehmet, Akpolat, Meryem, Demirci, Buket
Format: Article
Language:English
Subjects:
Acids
Animal models
Animals
Antioxidants
Apoptosis
Conflicts of interest
Diabetes
Diabetes mellitus
Ethics
Ischemia
Kidney diseases
Kidneys
Membranes
Metabolism
Nephropathy
Streptozocin
Tıp
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Gulle, Kanat
Arasli, Mehmet
Akpolat, Meryem
Demirci, Buket
description Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and Hematoxylin- Eosin stains. Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and longterm DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes. Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.
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subjects Acids
Animal models
Animals
Antioxidants
Apoptosis
Conflicts of interest
Diabetes
Diabetes mellitus
Ethics
Ischemia
Kidney diseases
Kidneys
Membranes
Metabolism
Nephropathy
Streptozocin
Tıp
title Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats
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