Hormonal changes in consecutive clomiphene citrate stimulation cycles and their effect on pregnancy rates

Objective: To determine the relationship between the cumulative effect of sequential clomiphene citrate (CC) treatments in unexplained infertile women with intercycle and intracycle serum hormone changes. Materials and Methods: Patients who received CC 50 mg in the first cycle (group I, n=34) as ovu...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of obstetrics and gynecology 2022-09, Vol.19 (3), p.221
Main Authors: Evrim Ebru Kovalak, Özyürek, Eser Şefik, Akgül, Özlem Karabay, Karacan, Tolga
Format: Article
Language:English
Subjects:
Body mass index
Estrogens
Hormones
Infertility
Menstruation
Normal distribution
Ovaries
Ovulation
Polycystic ovary syndrome
Pregnancy
Sperm
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To determine the relationship between the cumulative effect of sequential clomiphene citrate (CC) treatments in unexplained infertile women with intercycle and intracycle serum hormone changes. Materials and Methods: Patients who received CC 50 mg in the first cycle (group I, n=34) as ovulation induction and those who received CC 50 mg in the second consecutive cycle (group II, n=18) were compared. Basal (cycle days 2-5) and trigger day (the day that recombinant human chorionic gonadotropin is given) levels of gonadotropin and steroid hormones were measured. Results: The 17OHP increase on trigger day was found to be statistically significantly higher in group II compared to the basal day (p=0.083). The testosterone (T) response on the trigger day of the patients in group II was found to be statistically significantly higher than that in group I (p=0.023). The number of selected follicles was negatively correlated with a follicle-stimulating hormone decrease and positively correlated with an estradiol increase. Endometrial thickness was positively correlated with a luteinizing hormone increase, and cycle cancelation was positively correlated with decreased estradiol. Conclusion: Based on this study, it was concluded that the reason for the increased efficiency rate in successive cycles of CC may be the cumulative increase in T and 17OHP levels. However, this result was found not to affect the clinical pregnancy rate.
ISSN:2149-9322
2149-9330
DOI:10.4274/tjod.galenos.2022.40607