Long-term Kinetics of Alpha-fetoprotein in Chronic Hepatitis C Patients Treated with Direct-acting Antivirals and Possible Predictive Role of AFP Response to Treatment on Development of Hepatocellular Carcinoma

Objectives: To evaluate the post-treatment upto fourth-year kinetics of alpha-fetoprotein (AFP) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral (DAA) drugs. Materials and Methods: In this retrospective, single-center study, 182 patients (124 female, 58 male) with CHC...

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Bibliographic Details
Published in:Viral hepatit dergisi 2021-08, Vol.27 (2), p.49-52
Main Authors: Ulaşoğlu, Celal, Erkalma Şenateş, Banu, Yapalı, Suna, Dumanoğlu, Betül, Enc, Feruze, Çolak, Yaşar, Şenateş, Ebubekir
Format: Article
Language:English
Subjects:
Antiviral drugs
Conflicts of interest
Diabetes
Ethics
Females
Genotype & phenotype
Hepatitis C
Hypertension
Laboratories
Liver cancer
Liver cirrhosis
Risk factors
Surveillance
Ultrasonic imaging
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Summary:Objectives: To evaluate the post-treatment upto fourth-year kinetics of alpha-fetoprotein (AFP) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral (DAA) drugs. Materials and Methods: In this retrospective, single-center study, 182 patients (124 female, 58 male) with CHC treated with DAA were included in the study. Biochemistry and AFP were recruited from the hospital database. The data at pre-treatment, 3rd and 48th month after the end of treatment were evaluated. Results: Of the 182 patients, mean age was 58±12 (28-76), and forty-nine (27%) had cirrhosis. At month 3, the average decline of AFP was 35.6% (0.4-97.0). Early decline of AFP
ISSN:1307-9441
2147-2939
DOI:10.4274/vhd.galenos.2021.2021-5-3