Role of Tissue Markers on Predicting the Prognosis of Intermediate and High-risk Non-muscle Invasive Bladder Cancer

Objective: Investigating the recurrence of high-risk non-muscle invasive bladder cancer patients with the phosphohistone H3 (PPH3), P53, and Ki-67 as a predictive markers. Materials and Methods: A total of 46 patients with high-risk non-muscle invasive bladder cancer patients were included. All the...

Full description

Saved in:
Bibliographic Details
Published in:Üroonkoloji bülteni 2020-12, Vol.19 (4), p.177-181
Main Authors: Abbaslı, Abulfaz, Çitgez, Sinharib, Demirdağ, Çetin, Gürbüz, Ahmet, Erözenci, Ahmet
Format: Article
Language:English
Subjects:
Bladder cancer
Cell cycle
Disease
Investigations
Medical prognosis
Pathology
Proteins
Statistical analysis
Tumors
Urology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: Investigating the recurrence of high-risk non-muscle invasive bladder cancer patients with the phosphohistone H3 (PPH3), P53, and Ki-67 as a predictive markers. Materials and Methods: A total of 46 patients with high-risk non-muscle invasive bladder cancer patients were included. All the patients treated with bacillus Calmette-Guérin instillation. Patients were divided into two groups consisted of the with recurrence (group 1) and without recurrence (group 2). Assessment of mitotic cells only in metaphase that are stained with PPH3 immunhistochemically counted separately at 20 and 40 magnification in most intense areas under microscope. Immunhistochemically stained urothelial cells with P53 evaluation was based on 3 different scoring categories that are intense, extent, and the total score. Ki-67 immunhistochemical stained cells were calculated with ratio of counted positive stained cells in intense area to the total cells. Mann-Whitney U test was used. Results: There is no significant differences between the median value of PPH3 at 20 and 40 magnification in the two groups (p=0.620, p=0.241). P53 that was assessed with median values of the extent, intense, and total score had no significant findings between the two groups (p=0.377, p=0.102, p=0.380). Also, no significant results in median values of Ki-67 between the two groups found. Conclusion: These markers could not predict recurrence in our study, but in our opinion, significant results will be found if increasing case numbers and standard immunhistochemichal staining and assessment methods are used.
ISSN:2147-2122
2147-2270
DOI:10.4274/uob.galenos.2020.1382