Predicting Lamina Propria Invasion in Patients with Nonmuscle- invasive Bladder Cancer: Do RDW and NLR Really Work?

Objective: To determine the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) in predicting lamina propria invasion in bladder cancer. Materials and Methods: Eighty-eight patients with non-muscle-invasive bladder cancer were evaluated retrospectively. Th...

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Bibliographic Details
Published in:Üroonkoloji bülteni 2019-03, Vol.18 (1), p.6-9
Main Authors: Şentürk, Aykut Buğra, Ekici, Musa, Aydın, Cemil, Baykam, Mehmet Murat, Taş, Tuncay, Arda, Ersan, Çakıroğlu, Basri
Format: Article
Language:English
Subjects:
Bladder cancer
Colorectal cancer
Disease
Inflammation
Lymphocytes
Medical prognosis
Metastasis
Neutrophils
Nutritional status
Patients
Regression analysis
Tıp
Tumors
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Summary:Objective: To determine the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) in predicting lamina propria invasion in bladder cancer. Materials and Methods: Eighty-eight patients with non-muscle-invasive bladder cancer were evaluated retrospectively. The patients were divided into those with Ta tumors (group 1: n=36) and those with T1 tumors (group 2: n=52). For each patient, white blood cell, neutrophil, and leukocyte counts and RDW values were evaluated. Results: NLR was significantly lower in patients with Ta tumors. In addition, NLR below 3.22 was associated with 80.6% probability of Ta disease. RDW sensitivity in Ta non-muscle-invasive bladder tumors was much higher compared to T1 tumors. RDW below 15.35 was associated with 94.4% probability of Ta disease. Conclusion: NLR and RDW are basic blood parameters that physicians can assess easily. Our results indicate that a combination of NLR and RDW can help clinicians predict lamina propria invasion in non-muscle-invasive bladder tumors.
ISSN:2147-2122
2147-2270
DOI:10.4274/uob.galenos.2018.1099