Evaluation of glyphosate exposure on testosterone among U.S. adult men

Glyphosate is one of the most commonly used herbicide globally. It is considered an endocrine-disrupting chemical (EDC) that can affect the production and function of various hormones including testosterone. Testosterone is an important sex hormone in men that governs sexual development, function, m...

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Bibliographic Details
Published in:Human and ecological risk assessment 2023-07, Vol.29 (5-6), p.902-915
Main Authors: Glover, Frank, Barr, Dana, Eatman, Jasmin, Muncey, Wade, Del Giudice, Francesco, Belladelli, Federico, Seranio, Nicolas, Eisenberg, Michael L.
Format: Article
Language:English
Subjects:
Continuity (mathematics)
endocrine disruption
Endocrine disruptors
Evaluation
Exposure
Glyphosate
Herbicides
Hormones
Human exposure
Men
Mens health
Population studies
Quartiles
Regression analysis
Reproductive health
Risk factors
Sex hormones
Sociodemographics
Surveys
Testosterone
Variance analysis
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Summary:Glyphosate is one of the most commonly used herbicide globally. It is considered an endocrine-disrupting chemical (EDC) that can affect the production and function of various hormones including testosterone. Testosterone is an important sex hormone in men that governs sexual development, function, metabolism, and reproduction. Glyphosate has been associated with testosterone impairment in a number of experimental studies; however, the association between glyphosate exposure and testosterone among U.S. adult men in the general population is currently unknown. Data was leveraged from the National Health and Nutrition Examination Survey (NHANES), which is an annually conducted, population-based cross-sectional study. Urinary levels of glyphosate were quantified as measures of exposure. Total testosterone was quantified from the serum of adult men ages 18+, and a serum value of
ISSN:1080-7039
1549-7860
DOI:10.1080/10807039.2023.2195005