Antidiabetic Activity and Biochemical Parameter Estimation of Morus nigra in SD Rat

High-density lipoprotein levels increased in diabetic rats when Morus nigra hydro-alcoholic leaves extract was administered, while biochemical parameters like total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), creatinine, serum glutamate phosphotransferase (SGPT), urea, and serum...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2023-06, Vol.15 (6), p.1150-1155
Main Authors: Singh, Sunita, Sengar, Mukul, Singh, Deepak, Mishra, Vinay, Kushawaha, Jyoti, Giri, Balendu S, Singh, Dhananjay
Format: Article
Language:English
Subjects:
Animals
Antidiabetics
Diabetes
Drinking water
Drug dosages
Glucose
Humidity
Insulin
Metabolism
Osmosis
Parameter estimation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High-density lipoprotein levels increased in diabetic rats when Morus nigra hydro-alcoholic leaves extract was administered, while biochemical parameters like total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), creatinine, serum glutamate phosphotransferase (SGPT), urea, and serum glutamate oxaloacetic acid transferase (SGOT) decreased. Numerous plants have been used for their antidiabetic properties through a variety of mechanisms, including lowering hepatic gluconeogenesis, inhibiting glucose-6-phosphatase in addition to fructose-1, 6-biphosphatase in the liver, reducing intestinal glucose absorption, raising plasma insulin levels, and enhancing glucose tolerance5. Because of an increase in insulin release from pancreatic beta cells, hydro-alcoholic extract of Morus nigra leaves demonstrated considerable antidiabetic action in the current study. By graphing the relationship between blood glucose level and time (from 0 to 120 minutes), the decrease of blood glucose levels in rats was assessed. By comparing the percentage decrease in area under the curve of the plant sample and metformin of the controlled group, it was possible to determine the percentage decrease in blood glucose profile18.
ISSN:0975-1459