Dosimetric comparison of 3-dimensional conformal radiotherapy (3D-CRT) and volumetric-modulated arc therapy (VMAT) in locally advanced cancer cervix

Introduction:Dosimetric advantages of volumetric-modulated arc therapy (VMAT) over three-dimensional conformal radiotherapy (3D-CRT) are not established in a head-on comparison of a uniform group of locally advanced carcinoma of the cervix (LACC). Therefore, we conducted a dosimetric comparison of t...

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Bibliographic Details
Published in:Journal of radiotherapy in practice 2022-03, Vol.21 (1), p.60-67
Main Authors: Agrawal, Animesh, Hadi, Rahat, Rath, Satyajeet, Bharati, Avinav, Rastogi, Madhup, Khurana, Rohini, Sahni, Kamal, Sapru, Shantanu, Gandhi, Ajeet Kumar, Srivastava, Anoop Kumar, Mishra, Surendra Prasad
Format: Article
Language:English
Subjects:
Abdomen
Bladder
Cancer
Cancer therapies
Cervical cancer
Cervical carcinoma
Cervix
Computed tomography
Conformity
Disease
Homogeneity
Original Article
Parameters
Patients
Pelvis
Planning
Radiation therapy
Urinary bladder
Vagina
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Summary:Introduction:Dosimetric advantages of volumetric-modulated arc therapy (VMAT) over three-dimensional conformal radiotherapy (3D-CRT) are not established in a head-on comparison of a uniform group of locally advanced carcinoma of the cervix (LACC). Therefore, we conducted a dosimetric comparison of these two techniques in LACC patients.Materials and methods:Computed tomography (CT) data of histologically proven de novo LACC, including Stage IIB–IIIB and earlier stages deemed inoperable, were included in this prospective observational dosimetric study. Planning was initially done by 3D-CRT technique (dose of 45–50·4 Gy @ 1·8–2 Gy/# was used in the actual treatment), followed by VMAT planning and appropriate dosimetric comparisons were done in 39 cases.Results:For planning target volume coverage, D95, D98 and D100 (p < 0·0001 for all parameters) and V95 and V100 (p = 0·002 and
ISSN:1460-3969
1467-1131
DOI:10.1017/S1460396920000849