Synthesis and biological studies of novel hydroxyacetophenone-tetrazole hybrids

A series of novel hybrid compounds was synthesized where 2′-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H- and 13C-NMR, FT-IR, and HRMS method...

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Bibliographic Details
Published in:Organic communications 2023-04, Vol.16 (2), p.75-86
Main Authors: Dilek, Gulay, Disli, Ali, Yucesoy, Esin Eylem, Ozturk, Ali
Format: Article
Language:English
Subjects:
Alkylation
Analgesics
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
Clinical isolates
Drug resistance
Hybrids
NMR
Nuclear magnetic resonance
Pathogens
Tetrazoles
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Summary:A series of novel hybrid compounds was synthesized where 2′-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H- and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 µg/ml. 4a and 5d were the most active antibacterial members.
ISSN:1307-6175
1307-6175
DOI:10.25135/acg.oc.148.2302.2696