Stereoselective total synthesis of Pestalotioprolide C and C7-epi-Pestalotioprolide C

The total synthesis of 14 membered macrolide Pestalotioprolide C and C7-epi- Pestalotioprolide C were accomplished starting from commercially available D-Mannitol by Stereoselective synthetic approach. The key reactions involved are Mitsunobu reaction, Regioselective ring opening of chiral epoxide a...

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Bibliographic Details
Published in:Synthetic communications 2023-09, Vol.53 (17), p.1391-1397
Main Authors: Jami, Pradeep Kumar, Battula, Sreenivasa Rao, Parimi, Uma Devi, Syed, Tasqeeruddin
Format: Article
Language:English
Subjects:
14-membered macrolides
D-Mannitol
Mannitol
Metathesis
Mitsunobu reaction
Pestalotioprolide C
Ring opening
ring-closing metathesis reactions (RCM)
Stereoselectivity
Synthesis
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Summary:The total synthesis of 14 membered macrolide Pestalotioprolide C and C7-epi- Pestalotioprolide C were accomplished starting from commercially available D-Mannitol by Stereoselective synthetic approach. The key reactions involved are Mitsunobu reaction, Regioselective ring opening of chiral epoxide and ring-closing metathesis reactions (RCM).
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2023.2228945