Nanohybrid carbon nanodots-CuFe2O4 as selectively magnetofluorescent agent on tumor cells

• Published in: Journal of materials research 2023-07, Vol.38 (13), p.3416-3428
• Main Authors: Fahmi, Mochamad Z., Wibowo, Denika L. N., Aung, Yu-yu, Indrasari, Nindayu, Nikmah, Yatim L., Sakti, Satya C. W., Irzaman, Irzaman, Abdullah, Che A. C.
• Format: Article
• Language: English
• Subjects: Applied and Technical Physics; Biomaterials; Carbon; Chemistry and Materials Science; Contrast agents; Copper ferrite; Diagnosis; Fluorescence; Hyaluronic acid; Inorganic Chemistry; Magnetic materials; Materials Engineering; Materials research; Materials Science; Nanoparticles; Nanotechnology; Photoluminescence; System effectiveness; Toxicity; Tumors
• ISSN: 0884-2914; 2044-5326
• DOI: 10.1557/s43578-023-01066-x

The magnetic material with carbon nanodots as magnetofluorescent multi-agents was an effective way to determine cellular information in clinical diagnosis systems. However, exploring hyaluronic acid (HA) on magnetofluorescent is limited in combining with CuFe 2 O 4 . The present study reports a new design contrast agent as a hybrid carbon nanodots (CNDs–CuFe 2 O 4 –HA) by combining the fluorescence carbon nanodots (CNDs) and copper ferrite (CuFe 2 O 4 ) nanoparticles capsulated with HA. The as-prepared nanohybrid confirmed the unique properties through some important analytical techniques. The photoluminescence data showed an average diameter of the nanohybrid of about 104 nm and exhibited blue emission ( λ em  = 420 nm). The hybrid also showed the superparamagnetic behavior and saturated magnetization ( M s ) value of 0.63 emug −1 , which increased the positive contrast on T 1 -weight relaxation of MRI as well as its specific targeting to the tumor assessed by confocal microscopy. The effective nanohybrid particles also described remarkable fluorescence and non-toxicity features that are useful for clinical diagnosis information. Graphical abstract