Effect of Spanish Black Radish Extract Against Benzyne Induced Toxicity in Rats

Benzene is one of the main products of the petrochemical industry worldwide, which causes aplastic anemia and leukemia in both people and animals. This study was designed to examine the modulatory effects of black radish on Benzene-induced toxicity in male rats. Thirty-five rats were divided into 7...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2023-07, Vol.1215 (1), p.12060
Main Authors: Jabbar, Baneen Hayder, Al-Ali, Ibtisam A., Hussein, Khalid Ali
Format: Article
Language:English
Subjects:
Anemia
Aplastic anemia
Benzene
Cyclophosphamide
Kidney
Kidneys
Leukemia
Liver
Petrochemicals
Petrochemicals industry
Radishes
Spanish black radish
Spleen
Toxicity
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Summary:Benzene is one of the main products of the petrochemical industry worldwide, which causes aplastic anemia and leukemia in both people and animals. This study was designed to examine the modulatory effects of black radish on Benzene-induced toxicity in male rats. Thirty-five rats were divided into 7 groups (5 rats in each group), G1 negative control group; G2 positive control group (benzene treated group); G3 and G4 were treated after development of leukemia with Black radish aqueous extract (100mg/kg and 200 mg/kg respectively), while G5 and G6 were treated with Black radish ethanolic extract (100mg/kg and 200 mg/kg and G7 was treated with cyclophosphamide. Significant pathological variations in the liver, kidney and spleen tissues were detected in all experimental groups except for the control group. Our results indicate that benzyne induces irreversible adverse effects on the livers, kidneys, and spleen of rats.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/1215/1/012060