Characterization of Kaolinite Single Methoxy Nano-Sheets as Potential Carriers of Oxaliplatin Drug of Enhanced Loading, Release, and Cytotoxicity Properties During the Treatment of Colorectal Cancer

Kaolinite mineral was exfoliated into single nano-sheets (EXFK) and functionalized by methanol forming novel methoxy kaolinite nanosheet (MX/EXFK) as effective carrier of oxaliplatin drug (OXP). The functionalization of EXFK notably enhanced the loading properties to 433 mg/g (MX/EXFK) instead of 30...

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Published in:Journal of inorganic and organometallic polymers and materials 2023-07, Vol.33 (7), p.2111-2126
Main Authors: Alqahtani, Mashael D., Nasser, Nourhan, AlZahrani, Saleha A., Allam, Ahmed A., Abukhadra, Mostafa R.
Format: Article
Language:English
Subjects:
Cancer
Chemistry
Chemistry and Materials Science
Cytotoxicity
Encapsulation
Inorganic Chemistry
Kaolinite
Organic Chemistry
Polymer Sciences
Toxicity
Transport properties
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Summary:Kaolinite mineral was exfoliated into single nano-sheets (EXFK) and functionalized by methanol forming novel methoxy kaolinite nanosheet (MX/EXFK) as effective carrier of oxaliplatin drug (OXP). The functionalization of EXFK notably enhanced the loading properties to 433 mg/g (MX/EXFK) instead of 304.9 mg/g (EXFK). The loading reactions by EXFK and MX/EXFK follow the Pseudo-first order kinetics (R 2  > 0.94) and classic Langmuir isotherm (R 2  = 0.99). MX/EXFK shows enhanced active sites density (109.9 mg/g) as compared to 66.3 mg/g (EXFK) and each site can be loaded with 4 molecules by multi-molecular mechanism. The encapsulation energy (
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-023-02634-8