Role of ChREBP and SREBP-1c in gestational diabetes: two key players in glucose and lipid metabolism

Background Gestational diabetes mellitus (GDM) is any degree of glucose intolerance diagnosed during pregnancy. Metabolic abnormalities in GDM are associated with pancreatic β-cell destruction and decreased insulin sensitivity. Carbohydrate-responsive element-binding protein (ChREBP) and sterol regu...

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Published in:International journal of diabetes in developing countries 2023-08, Vol.43 (4), p.587-591
Main Authors: Eroglu, Nurgul, Yerlikaya, Fatma Humeyra, Onmaz, Duygu Eryavuz, Colakoglu, Mehmet Cengiz
Format: Article
Language:English
Subjects:
Beta cells
Carbohydrate metabolism
Diabetes
Diabetes mellitus
Family Medicine
General Practice
Glucose metabolism
Glucose tolerance
Health Administration
Homeostasis
Insulin resistance
Intolerance
Lipid metabolism
Medicine
Medicine & Public Health
Original Article
Pregnancy complications
Sterol regulatory element-binding protein
Transcription factors
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Summary:Background Gestational diabetes mellitus (GDM) is any degree of glucose intolerance diagnosed during pregnancy. Metabolic abnormalities in GDM are associated with pancreatic β-cell destruction and decreased insulin sensitivity. Carbohydrate-responsive element-binding protein (ChREBP) and sterol regulatory element-binding protein-1c (SREBP-1c) are two transcription factors that play a key role in carbohydrate and lipid metabolism homeostasis. Our aim in this study was to elucidate the role of these proteins in GDM. Methods The study included 50 pregnant women diagnosed with GDM and 52 pregnant women with normal glucose tolerance. Maternal blood samples were collected from pregnant women between the 24th and 28th weeks of pregnancy. Serum SREBP-1c and ChREBP levels were measured with commercial ELISA kits according to the manufacturer’s instructions. Results Serum ChREBP ( p =0.044) and SREBP1c ( p =0.042) levels of pregnant women with normal glucose tolerance were found to be statistically significantly higher than women with GDM.
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-022-01050-x