Donepezil-based combination therapy for Alzheimer’s disease and related neuropathies

Combination therapy has birthed improved treatment possibilities for a number of complex and degenerative diseases in the world, which include cancer, diabetes and cardiovascular disease, and has been encouraged for use in the treatment of Alzheimer’s disease (AD), as a result of its complex patholo...

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Bibliographic Details
Published in:Comparative clinical pathology 2023-08, Vol.32 (4), p.699-708
Main Authors: Ekundayo, Bidemi Emmanuel, Obafemi, Tajudeen Olabisi, Adewale, Olusola Bolaji, Oyinloye, Babatunji Emmanuel
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cardiovascular diseases
Clinical trials
Combination therapy
Dementia
Diabetes
Diabetes mellitus
Diabetic neuropathy
Donepezil
Hematology
Medicine
Medicine & Public Health
Memantine
Neurodegenerative diseases
Oncology
Oxidative stress
Pathology
Poisoning
Review Article
Task forces
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Summary:Combination therapy has birthed improved treatment possibilities for a number of complex and degenerative diseases in the world, which include cancer, diabetes and cardiovascular disease, and has been encouraged for use in the treatment of Alzheimer’s disease (AD), as a result of its complex pathological pathways. The combination of memantine and donepezil was approved for use to treat moderate-to-severe AD cases in 2014. Studies have however continued to investigate many other possible combination therapies for the treatment of AD. This article highlights some of the recent combination therapies involving the use of donepezil.
ISSN:1618-565X
1618-5641
1618-565X
DOI:10.1007/s00580-023-03487-w