Synovitis, acne, pustulosis, hyperostosis, osteitis syndrome with invisible organizing pneumonia: A case report

We report the case of a 59‐year‐old female patient, presenting with pustular rash on both hands and pain in the lumbosacral part and left lower limb. A magnetic resonance imaging examination of the left leg was undertaken and the result showed that a malignant lesion with bone destruction of the lef...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2023-08, Vol.26 (8), p.1586-1589
Main Authors: Kang, Tianlun, Xi, Yajing, Li, Yingzi, Wei, Shufeng, Hou, Xiujuan, Li, Chen
Format: Article
Language:English
Subjects:
Acne
Acne Vulgaris
Acquired Hyperostosis Syndrome - diagnosis
Acquired Hyperostosis Syndrome - diagnostic imaging
Antinuclear antibodies
Bone imaging
Bone tumors
Case reports
Computed tomography
Erythrocyte sedimentation rate
Female
Femur
Histocompatibility antigen HLA
Humans
Hyperostosis
Lung cancer
Magnetic resonance imaging
Middle Aged
organized pneumonia
Organizing Pneumonia
Osteitis
osteitis syndrome
Pneumonia
pulmonary pathology
Pustulosis
Rheumatoid factor
Scintigraphy
Synovitis
Technetium
tripterygium glycosides tablets
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Summary:We report the case of a 59‐year‐old female patient, presenting with pustular rash on both hands and pain in the lumbosacral part and left lower limb. A magnetic resonance imaging examination of the left leg was undertaken and the result showed that a malignant lesion with bone destruction of the left femoral shaft could not be excluded. Subsequently, bone tumor was excluded by pathological examination. Lung computed tomography scan showed patchy consolidation and cord shadow in the middle left lung. Subsequently, lung cancer was excluded by pathological examination, and the histopathological changes of lung were consistent with those of organized pneumonia. Blood tests revealed elevated C‐reactive protein and erythrocyte sedimentation rate. Antinuclear antibody, rheumatoid factor, and human leukocyte antigen‐B27 were unremarkable. Whole body bone scintigraphy via technetium 99m‐methyl diphosphonate showed increased radionuclide uptake in the left middle femur. Based on her clinical manifestations, imaging results and bone scintigraphy, the patient was diagnosed as having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. Loxoprofen and Tripterygium wilfordii Hook F led to impressive clinical and radiologic improvement.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.14631