Inside Back Cover: Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition (Angew. Chem. Int. Ed. 32/2023)

O‐fucosylated glycan epitopes of membrane‐bound mucin glycoproteins are key ligands of many bacterial lectins. In their Research Article (e202302437), Ulrika Westerlind and co‐workers describe the synthesis of fucosylated mucin glycopeptides using a chemoenzymatic approach. Starting from simple buil...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2023-08, Vol.62 (32), p.n/a
Main Authors: Behren, Sandra, Yu, Jin, Pett, Christian, Schorlemer, Manuel, Heine, Viktoria, Fischöder, Thomas, Elling, Lothar, Westerlind, Ulrika
Format: Article
Language:English
Subjects:
Amino acids
Bacteria
Epitopes
Fucose
Glycan
Glycopeptides
Glycoproteins
Glycosylation
Lectins
Microarrays
Mucin
Peptides
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Summary:O‐fucosylated glycan epitopes of membrane‐bound mucin glycoproteins are key ligands of many bacterial lectins. In their Research Article (e202302437), Ulrika Westerlind and co‐workers describe the synthesis of fucosylated mucin glycopeptides using a chemoenzymatic approach. Starting from simple building blocks, Fmoc‐protected glycosylated amino acids were prepared and incorporated into peptides and enzymatically diversified. Bacteria lectin interactions were then elucidated on glycopeptide microarrays.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202307867