Differential effect of radiation on endothelial cell function in rectal cancer and normal rectum

Background: Chronic radiation injury of the intestine is associated with significant underexpression of a potent physiological anticoagulant, endothelial cell thrombomodulin (TM). This study compared early and late radiation-induced changes in endothelial TM, urokinase plasminogen activator (uPA), a...

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Bibliographic Details
Published in:The American journal of surgery 1998-12, Vol.176 (6), p.642-647
Main Authors: Richter, Konrad K, Fink, Louis M, Hughes, Bradley M, Shmaysani, Hasan M, Sung, Ching-Ching, Hauer-Jensen, Martin
Format: Article
Language:English
Subjects:
Aged
Angiogenesis
Anticoagulants
Cancer
Cancer therapies
Colorectal cancer
Cytokines
Endothelial cells
Endothelium - cytology
Endothelium - physiology
Extracellular matrix
Female
Growth factors
Humans
Image analysis
Image processing
Immunohistochemistry
Immunoreactivity
Intestine
Irradiation
Laboratories
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Pathogenesis
Proctitis
Proteins
Radiation
Radiation effects
Radiation injuries
Radiation therapy
Radiotherapy, Adjuvant - adverse effects
Rectal Neoplasms - radiotherapy
Rectum
Rectum - cytology
Rectum - radiation effects
Thrombomodulin - biosynthesis
Thrombomodulin - radiation effects
Toxicity
Transforming Growth Factor beta - biosynthesis
Transforming Growth Factor beta - radiation effects
Transforming growth factor-b
Tumors
U-Plasminogen activator
Urokinase
Urokinase-Type Plasminogen Activator - biosynthesis
Urokinase-Type Plasminogen Activator - radiation effects
Variance analysis
Vessels
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Summary:Background: Chronic radiation injury of the intestine is associated with significant underexpression of a potent physiological anticoagulant, endothelial cell thrombomodulin (TM). This study compared early and late radiation-induced changes in endothelial TM, urokinase plasminogen activator (uPA), and transforming growth factor β (TGF-β) in normal rectum and tumors. Methods: Rectal resection specimens from 27 patients were analyzed: Nine patients underwent primary resection of rectal cancer, 11 tumors were resected after neo-adjuvant radiotherapy, and 7 because of local recurrence after prior resection and adjuvant radiotherapy. TM, uPA, and extracellular matrix-associated TGF-β immunoreactivity were assessed using computerized image analysis. Results: Multivariate analysis revealed that tumors had more TM-positive vessels ( P = 0.003), more uPA-positive cells ( P
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(98)00280-3