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Interactions between outcomes and tumor response to preoperative cisplatin-sensitized radiotherapy in advanced head and neck cancer
Whether or not tumor response to chemotherapy-sensitized radiation therapy (CTRT) for head and neck cancer leads to an improved outcome is unknown. Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retro...
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| Published in: | The American journal of surgery 1997-11, Vol.174 (5), p.527-531 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 531 |
| container_issue | 5 |
| container_start_page | 527 |
| container_title | The American journal of surgery |
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| creator | D. Goodman, Martin Tarnoff, Michael Kain, Michael J. Slotman, Gus |
| description | Whether or not tumor response to chemotherapy-sensitized radiation therapy (CTRT) for head and neck cancer leads to an improved outcome is unknown.
Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retrospectively regarding clinical demographics, staging, and survival status.
Twenty-one (57%) patients had a histologic complete response (HCR) and 16 (43%) had a partial (PR) (9) or clinical complete (7) response (CCR). Tumor response of N
1 versus N
2–3 nodal disease showed 6 (75%) HCR and 4 (25%). Fiveyear disease-free survival overall was 82% for HCR versus 38% for PR/CCR (
P < 0.05). Disease specific 5-year survival was 100% for HCR versus 27% for PR/CCR (
P |
| doi_str_mv | 10.1016/S0002-9610(97)00151-7 |
| format | article |
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Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retrospectively regarding clinical demographics, staging, and survival status.
Twenty-one (57%) patients had a histologic complete response (HCR) and 16 (43%) had a partial (PR) (9) or clinical complete (7) response (CCR). Tumor response of N
1 versus N
2–3 nodal disease showed 6 (75%) HCR and 4 (25%). Fiveyear disease-free survival overall was 82% for HCR versus 38% for PR/CCR (
P < 0.05). Disease specific 5-year survival was 100% for HCR versus 27% for PR/CCR (
P <0.002).
Histologic complete response to CTRT for head and neck cancer is associated with increased survival and encouraging disease free status. Response to CTRT is inversely proportional to lymphatic tumor load.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(97)00151-7</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cancer ; Chemotherapy ; Cisplatin ; Diseases of the upper aerodigestive tract ; Ent and stomatology ; Head & neck cancer ; Medical sciences ; Radiation ; Radiation therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Survival ; Tumors</subject><ispartof>The American journal of surgery, 1997-11, Vol.174 (5), p.527-531</ispartof><rights>1997 Excerpta Medica, Inc. All rights reserved</rights><rights>1998 INIST-CNRS</rights><rights>1997. Excerpta Medica, Inc. All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-6f431880a3583361f59acf863b22f686bcd3a482aead0a46eca35877bd98a09c3</citedby><cites>FETCH-LOGICAL-c364t-6f431880a3583361f59acf863b22f686bcd3a482aead0a46eca35877bd98a09c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2076631$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>D. Goodman, Martin</creatorcontrib><creatorcontrib>Tarnoff, Michael</creatorcontrib><creatorcontrib>Kain, Michael</creatorcontrib><creatorcontrib>J. Slotman, Gus</creatorcontrib><creatorcontrib>Southern New Jersey Head and Neck Cancer Treatment Group</creatorcontrib><title>Interactions between outcomes and tumor response to preoperative cisplatin-sensitized radiotherapy in advanced head and neck cancer</title><title>The American journal of surgery</title><description>Whether or not tumor response to chemotherapy-sensitized radiation therapy (CTRT) for head and neck cancer leads to an improved outcome is unknown.
Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retrospectively regarding clinical demographics, staging, and survival status.
Twenty-one (57%) patients had a histologic complete response (HCR) and 16 (43%) had a partial (PR) (9) or clinical complete (7) response (CCR). Tumor response of N
1 versus N
2–3 nodal disease showed 6 (75%) HCR and 4 (25%). Fiveyear disease-free survival overall was 82% for HCR versus 38% for PR/CCR (
P < 0.05). Disease specific 5-year survival was 100% for HCR versus 27% for PR/CCR (
P <0.002).
Histologic complete response to CTRT for head and neck cancer is associated with increased survival and encouraging disease free status. Response to CTRT is inversely proportional to lymphatic tumor load.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Diseases of the upper aerodigestive tract</subject><subject>Ent and stomatology</subject><subject>Head & neck cancer</subject><subject>Medical sciences</subject><subject>Radiation</subject><subject>Radiation therapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Survival</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkEtPAyEUhYnRxPr4CSYkutDFKAwzwKyMaXw0aeJCXRPK3IloCyPQGt36x2Va060r4PKde3IOQieUXFJC-dUTIaQsGk7JeSMuCKE1LcQOGlEpmoJKyXbRaIvso4MY3_KT0oqN0M_EJQjaJOtdxDNInwAO-2UyfgERa9fitFz4gAPEPiOAk8d9AN9nVbIrwMbGfp6vrojgok32G1ocdGt9es1M_4Wtw7pdaWfyxyvodr3VgXnHZhiGI7TX6XmE47_zEL3c3T6PH4rp4_1kfDMtDONVKnhXsZyGaFZLxjjt6kabTnI2K8uOSz4zLdOVLHW2ILriYAZSiFnbSE0aww7R6WZvH_zHEmJSb34ZXLZUpaxEVQtKeabqDWWCjzFAp_pgFzp8KUrU0Lda962GMlUj1LpvJbLu7G-7jkbPu5Cz2bgVl0RwzmjGrjcY5KQrC0FFY2HoxgYwSbXe_mP0C6fIlvQ</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>D. Goodman, Martin</creator><creator>Tarnoff, Michael</creator><creator>Kain, Michael</creator><creator>J. 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Goodman, Martin ; Tarnoff, Michael ; Kain, Michael ; J. Slotman, Gus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-6f431880a3583361f59acf863b22f686bcd3a482aead0a46eca35877bd98a09c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Diseases of the upper aerodigestive tract</topic><topic>Ent and stomatology</topic><topic>Head & neck cancer</topic><topic>Medical sciences</topic><topic>Radiation</topic><topic>Radiation therapy</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D. Goodman, Martin</creatorcontrib><creatorcontrib>Tarnoff, Michael</creatorcontrib><creatorcontrib>Kain, Michael</creatorcontrib><creatorcontrib>J. 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Goodman, Martin</au><au>Tarnoff, Michael</au><au>Kain, Michael</au><au>J. Slotman, Gus</au><aucorp>Southern New Jersey Head and Neck Cancer Treatment Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions between outcomes and tumor response to preoperative cisplatin-sensitized radiotherapy in advanced head and neck cancer</atitle><jtitle>The American journal of surgery</jtitle><date>1997-11-01</date><risdate>1997</risdate><volume>174</volume><issue>5</issue><spage>527</spage><epage>531</epage><pages>527-531</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Whether or not tumor response to chemotherapy-sensitized radiation therapy (CTRT) for head and neck cancer leads to an improved outcome is unknown.
Forty patients who received preoperative cisplatin plus simultaneous radiotherapy for operable stage III and IV head and neck cancer were reviewed retrospectively regarding clinical demographics, staging, and survival status.
Twenty-one (57%) patients had a histologic complete response (HCR) and 16 (43%) had a partial (PR) (9) or clinical complete (7) response (CCR). Tumor response of N
1 versus N
2–3 nodal disease showed 6 (75%) HCR and 4 (25%). Fiveyear disease-free survival overall was 82% for HCR versus 38% for PR/CCR (
P < 0.05). Disease specific 5-year survival was 100% for HCR versus 27% for PR/CCR (
P <0.002).
Histologic complete response to CTRT for head and neck cancer is associated with increased survival and encouraging disease free status. Response to CTRT is inversely proportional to lymphatic tumor load.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><doi>10.1016/S0002-9610(97)00151-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1997-11, Vol.174 (5), p.527-531 |
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| subjects | Biological and medical sciences Cancer Chemotherapy Cisplatin Diseases of the upper aerodigestive tract Ent and stomatology Head & neck cancer Medical sciences Radiation Radiation therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Survival Tumors |
| title | Interactions between outcomes and tumor response to preoperative cisplatin-sensitized radiotherapy in advanced head and neck cancer |
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