Effect of shrimp shell chitosan on re-epithelialization of healing processes of excision wounds in white rats (Rattus norvegicus)

Excision wounds are wounds caused by sharp objects cutting the tissues. Chitosan in wound healing can accelerate cell regeneration (reepithelialization). The aim of this study was to determine the effect of shrimp shell chitosan on the reepithelization of the excision wound healing process in white...

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Bibliographic Details
Main Authors: Permatasari, Fitri Agnes, Yunita, Maya Nurwartanti, Plumeriastuti, Hani, Arimbi, Fikri, Faisal, Wibawati, Prima Ayu
Format: Conference Proceeding
Language:English
Subjects:
Chitosan
Iodine
Ointments
Rats
Shrimps
Wound healing
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Summary:Excision wounds are wounds caused by sharp objects cutting the tissues. Chitosan in wound healing can accelerate cell regeneration (reepithelialization). The aim of this study was to determine the effect of shrimp shell chitosan on the reepithelization of the excision wound healing process in white rats. This research used 20 male rats. Rats divided into 5 groups: C-(excision wound+ointment base without shrimp chitosan), C+(excision wound+10% povidone iodine), T1 (excision wound+shrimp shell chitosan ointment 1.5%), T2 (excision wound+shrimp shell chitosan ointment 2.5%), and T3 (excision wounds+shrimp shell chitosan ointment 5 %). Therapy was done once a day for 14 days. The results of the reepithelialization score were analyzed by Kruskal-Wallis which showed a significant difference (p
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0118064