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Development of Doxorubicin Complex with Nanoparticles Based on Sodium Alginate and Viologen Calix[4]resorcinol to Enhance Selectivity of the Cytotoxic Action

A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) has been obtained. Using a set of physicochemical methods, the polymer–macrocycle ratio, at which stable nanoparticles are formed, has been found and th...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-06, Vol.93 (6), p.1409-1419
Main Authors: Kashapov, R. R., Razuvayeva, Yu. S., Ziganshina, A. Yu, Sapunova, A. S., Voloshina, A. D., Salnikov, V. V., Zakharova, L. Ya
Format: Article
Language:English
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Summary:A biocompatible supramolecular system based on sodium alginate and viologen calix[4]resorcinol for encapsulation of doxorubicin hydrochloride (DOX) has been obtained. Using a set of physicochemical methods, the polymer–macrocycle ratio, at which stable nanoparticles are formed, has been found and their morphological characteristics have been determined. It has been shown that the increase in the concentration of calix[4]resorcinol leads to the increase in the size of nanoparticles, their zeta potential being changed from negative to positive values. It has been established that the optimal supramolecular system for DOX binding is a composition with a macrocycle–polymer ratio of 1 : 50, and a change in the components ratio can induce the drug release. The effect of encapsulated DOX on the physicochemical and biological properties of the supramolecular system has been shown.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223060129