New Sesquiterpene Lactone via Fungal Transformation of Rhizopus oryzae KX685359: Antimicrobial In-Vitro and In-Silico Study

• Published in: Catalysis letters 2023-09, Vol.153 (9), p.2624-2632
• Main Authors: Alshammari, Shifaa O., Abd El Aty, Abeer A., Hegazy, Mohamed-Elamir F.
• Format: Article
• Language: English
• Subjects: Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Biological effects; Catalysis; Chemistry; Chemistry and Materials Science; Drug resistance in microorganisms; E coli; Fungi; Industrial Chemistry/Chemical Engineering; Metabolites; Organometallic Chemistry; Physical Chemistry; Plant metabolites; Propionic acid; Substrates; Terpenes; Yeast
• ISSN: 1011-372X; 1572-879X
• DOI: 10.1007/s10562-022-04202-0

There is an urgent need for new chemical structures to develop drugs as a result of the increasing number of viruses and pathogenic bacteria that have the ability to resist established treatments. Phytochemical screening on Pulicaria species have yielded a lot of compounds specially terpenoids, importantly though, some compounds have been found to have a potent bioactivity. Pulicaria undulata plants considered as a productive source for the effective biologically secondary metabolites. Herein, 2α-Hydroxyalantolactone ( 1 ), a major secondary metabolite, was enzymatically transformed by Rhizopus oryzae KX685359 fungal isolate. The fungal transformation affords a new transformed metabolite2-(alantolactonyloxy) propanoic acid (2 ) and know alantolactone-2α-acetate ( 3 ). Antimicrobial assessment of the substrate and transformed compounds disclosed the moderate antimicrobial activity of compound ( 3 ) against Gram-negative E. coli , Gram-positive L. cereus and the unicellular yeast C. albicans. Graphical Abstract