Chemical Components of Thymbra spicata subsp. spicata L. Essential Oil and Its In Vitro Physiological Effects on Human Origin Cell Lines

Thymbra spicatasubsp. spicataL. is a member of the Lamiaceae family, which is used in Türkiye against various health issues among other uses. The main components of T. spicata essential oil (TE) were identified as carvacrol (52.3%) and p-cymene (21.1%) using GC-FID and GC/MS. The in vitro effects of...

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Bibliographic Details
Published in:Records of natural products 2023-07, Vol.17 (4), p.628-647
Main Authors: Özdemir Nath, Ebru, Gündoğan, Gül İpek, Kartal, Murat
Format: Article
Language:English
Subjects:
Cell growth
Chemical compounds
Oils & fats
Online Access:Get full text
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Summary:Thymbra spicatasubsp. spicataL. is a member of the Lamiaceae family, which is used in Türkiye against various health issues among other uses. The main components of T. spicata essential oil (TE) were identified as carvacrol (52.3%) and p-cymene (21.1%) using GC-FID and GC/MS. The in vitro effects of TE on Miapaca-2 and HUVEC cell lines were reported for the first time. The initial results showed that TE applied to Miapaca-2 cell lines at concentrations of ≥62.18 g/mL for 48 hours could reduce cell growth and induce apoptosis. The application of relatively high concentrations of TE (≥82.91 g/mL) significantly (P
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.387.23.01.2671