Amelioration of high fat diet induced hyperlipidemia by methanol extract of Tephrosia calophylla in wistar rats

Introduction A major risk factor for the onset and progression of cardiovascular disorders is hyperlipidemia which is characterized by elevated levels cholesterol, triglycerides, cholesterol esters VLDL and LDL cholesterol and also reduced concentrations HDL in blood1,2 [1,2]. [...]the objective of...

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Published in:Journal of pharmaceutical sciences and research 2023-07, Vol.15 (7), p.1191-1193
Main Authors: A, Sowmya B, C, Ramesh, Rawal, Pinkey, J, Ranjitha C, L, Anns Maria
Format: Article
Language:English
Subjects:
Angina pectoris
Animals
Atherosclerosis
Cancer
Cardiovascular disease
Cerebrovascular disease
Cholesterol
Diabetes
Diet
Drug dosages
Flavonoids
Folklore
Heart
Herbal medicine
High density lipoprotein
Hyperlipidemia
Ischemia
Lipids
Liver
Low density lipoprotein
Medicine
Phenols
Phytochemicals
Proteins
Triglycerides
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Summary:Introduction A major risk factor for the onset and progression of cardiovascular disorders is hyperlipidemia which is characterized by elevated levels cholesterol, triglycerides, cholesterol esters VLDL and LDL cholesterol and also reduced concentrations HDL in blood1,2 [1,2]. [...]the objective of the present study is to evaluate and provide scientific data for the hepatoprotective potentials of Tephrosia calophylla against thioacetamide induced liver damage in experimental rats. Evaluation of anti-hyperlipidemic activity of methanol extracts In the present study conducted to determine antihyperlipidemic activity of methanol extract of Tephrosia calophylla ingestion of high fat diet caused significant weight gain and also significant increase in the Total cholserol, Triglycerides, LDL and VLDL concentrations in the vehicle control group compare to normal animals. Discussion Atherosclerosis and its accompanying diseases, such as peripheral vascular disease, ischemic cerebrovascular disease, and coronary heart disease (CHD), are largely brought on by hyperlipidemia.
ISSN:0975-1459