Comparison of Single Vital Capacity Breath with Breath Holding Versus Three Vital Capacity Breath Induction with Sevoflurane in Adults by BIS Monitoring: A Prospective Randomized Study

Earlier studies using varying concentrations of sevoflurane were done on Caucasian population with above techniques but none comparing them with BIS or any objective parameters. [...]their results cannot be postulated for our population due to pharmacogenomics variabilities. Materials And Methods: T...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2023-07, Vol.15 (7), p.1176-1181
Main Authors: R, Vyshnavi, Nanda, Ananya, Vandana, Pakhare, Gopinath, Ramachandran, Dhanalakshmi, Kalyani Surya, Vamshidhar, Malipeddi
Format: Article
Language:English
Subjects:
Anesthesia
Blood pressure
Gases
Hemodynamics
Patients
Surgery
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Summary:Earlier studies using varying concentrations of sevoflurane were done on Caucasian population with above techniques but none comparing them with BIS or any objective parameters. [...]their results cannot be postulated for our population due to pharmacogenomics variabilities. Materials And Methods: The prospective randomized comparative study was carried out in a tertiary hospital, over a period of one year from August 2019-2020, after Institutional Ethics Committee approval (ESICMC/SNR/IEC- DNB/S003/08/2019 dated 29/08/2019) and registered at Clinical Trials Registry- India (CTRI/2020/05/025303 dated 22/05/2020). (Figure-1 CONSORT DIAGRAM) Subjects of either gender in the age group of 18-55 years belonging to ASA PS I-II (American Society of Anaesthesiologist physical status) undergoing elective surgery under general anaesthesia who were willing to comply with the instructions for vital capacity breathing and breath holding were included in the study. Haemodynamic parameters like PR, SBP, DBP and RR before induction, Mean preoperative breath holding time (BHT) and BIS were comparable between both groups and p value was statistically not significant (Table 1).
ISSN:0975-1459