Easy and efficient direct conversion of aryl nitrile into aryl amide

Aryl amides and amide derivatives are important functionality in drug and drug discovery, as many drugs have it as an integral part. However, the synthesis of amide requires the condensation or coupling of amines which is a tedious or costly approach. Herein we disclosed two easy and convenient meth...

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Bibliographic Details
Published in:Research on chemical intermediates 2023-09, Vol.49 (9), p.3951-3962
Main Authors: Kumar, Sumit, Ambatwar, Ramesh, Khatik, Gopal L.
Format: Article
Language:English
Subjects:
Amides
Amines
Aromatic compounds
Catalysis
Chemistry
Chemistry and Materials Science
Direct conversion
Inorganic Chemistry
Physical Chemistry
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Summary:Aryl amides and amide derivatives are important functionality in drug and drug discovery, as many drugs have it as an integral part. However, the synthesis of amide requires the condensation or coupling of amines which is a tedious or costly approach. Herein we disclosed two easy and convenient methods for directly synthesizing aryl amide using aryl nitrile in a short time with good to excellent yield via base-driven partial hydrolysis.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-023-05062-y