Polymer-based Electrochemical Sensor: Fast, Accurate, and Simple Insulin Diagnostics Tool

Study of the use of polymers with higher conductivity like polypyrrole, and polyaniline in the electrochemical insulin sensors can overcome the drawbacks arising from the ongoing use of non-conductive polymer membrane. Conductive polymer membranes maintain the positive properties of polymers, like i...

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Bibliographic Details
Published in:Electrocatalysis 2023-09, Vol.14 (5), p.697-707
Main Authors: Šišoláková, Ivana, Gorejová, Radka, Chovancová, Frederika, Shepa, Jana, Ngwabebhoh, Fahanwi Asabuwa, Fedorková, Andrea Straková, Sáha, Petr, Oriňaková, Renáta
Format: Article
Language:English
Subjects:
Catalysis
Chemical sensors
Chemistry
Chemistry and Materials Science
Chitosan
Conducting polymers
Electrochemistry
Electrodes
Energy Systems
Insulin
Membranes
Nanoparticles
Nickel
Oxidation
Physical Chemistry
Polyanilines
Polymers
Polypyrroles
Sensors
Stability analysis
Surface stability
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Summary:Study of the use of polymers with higher conductivity like polypyrrole, and polyaniline in the electrochemical insulin sensors can overcome the drawbacks arising from the ongoing use of non-conductive polymer membrane. Conductive polymer membranes maintain the positive properties of polymers, like improved stability, reproducibility, and even increase the current response of the prepared sensor toward insulin oxidation. Three different screen-printed electrodes modified with polyaniline, polypyrrole, or chitosan with electrochemically deposited nickel nanoparticles ensuring insulin oxidation were prepared. The electrode morphology was examined via SEM with EDX analysis. Also, the electroactive surface area and stability were determined by voltammetric methods. Based on the results, the SPCEs modified by polypyrrole and nickel nanoparticles were determined as the most appropriate for the insulin determination. The NiNPs-PPy-SPCE exhibited a linear range (500 nM–5 µM), a low-down limit of detection (38 nM), high sensitivity (3.98 µA/µM), and excellent result from insulin determination in real samples (human blood serum). The results confirmed the high potential of developed sensor for future research focused on detection of insulin via electrochemistry methods in clinical samples. Graphical Abstract
ISSN:1868-2529
1868-5994
DOI:10.1007/s12678-023-00827-w