Base‐Promoted Difunctionalization of Alkynes: One‐Pot Synthesis of Polysubstituted Chromones

A transition‐metal‐free one‐pot procedure for the difunctionalization of alkynes by C−C triple bond oxidation and transformation towards chromone derivatives has been developed. It involves cascade reactions for carbonylation of alkynes, base‐promoted C−C σ‐bond cleavage, and intramolecular cyclizat...

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Bibliographic Details
Published in:European journal of organic chemistry 2023-08, Vol.26 (32), p.n/a
Main Authors: Wang, Mengdan, Cheng, Lu, Ma, Junying, Lu, Weiwei, Wang, Junling
Format: Article
Language:English
Subjects:
Alkynes
Carbonyls
Cascade chemical reactions
C−C triple bond oxidation
difunctionalization of alkynes
one-pot
Oxidation
Synthesis
transition-metal-free
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Summary:A transition‐metal‐free one‐pot procedure for the difunctionalization of alkynes by C−C triple bond oxidation and transformation towards chromone derivatives has been developed. It involves cascade reactions for carbonylation of alkynes, base‐promoted C−C σ‐bond cleavage, and intramolecular cyclization. This procedure provides an efficient protocol for the synthesis of polysubstituted chromones from readily available starting materials. A transition metal‐free one‐pot procedure for the difunctionalization of alkynes has been developed.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202300456