Synaptic Aspects of the Pathogenesis of Autism, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease

Recently, data have been obtained that indicate that an important role in the pathogenesis of many neurodegenerative diseases and autism spectrum disorders is played by a violation of the functioning of synapses both at the pre- and postsynaptic level. Of particular interest may be information about...

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Bibliographic Details
Published in:Biophysics (Oxford) 2023-02, Vol.68 (1), p.137-145
Main Authors: Khairullin, A. E., Mukhamedyarov, M. A., Grishin, S. N., Teplov, A. Yu, Nagiev, K. K., Ziganshin, A. U.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Autism
Biological and Medical Physics
Biophysics
Medical Biophysics
Neurodegeneration
Neurodegenerative diseases
Pathogenesis
Physics
Physics and Astronomy
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Summary:Recently, data have been obtained that indicate that an important role in the pathogenesis of many neurodegenerative diseases and autism spectrum disorders is played by a violation of the functioning of synapses both at the pre- and postsynaptic level. Of particular interest may be information about synaptic disorders in the early, asymptomatic stages of the disease, when it is potentially still possible to prevent mass degeneration of neurons. The correction of synaptic transduction at this stage is probably very effective in terms of the therapy of a number of similar diseases. This review is devoted to the role of synaptic structures in the pathogenesis of Alzheimer’s disease, amyotrophic lateral sclerosis and autism spectrum disorders.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350923010086