Heme and Globin Conformations in Fractionated Rat Erythrocytes by Raman Spectroscopy

Conformational changes of heme and globin in fractionated rat erythrocytes were studied by Raman spectroscopy. Normal isoforms (common variants) of hemoglobin, which plays a key role in oxygen transport and a protective role in oxidative stress, were shown to predominate (more than 80%) in the rat b...

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Bibliographic Details
Published in:Biophysics (Oxford) 2023-02, Vol.68 (1), p.24-30
Main Authors: Yushkov, B. G., Zuev, M. G., Brilliant, S. A., Vasin, A. A.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Erythrocytes
Heme
Hemoglobin
Isoforms
Molecular Biophysics
Oxidative stress
Physics
Physics and Astronomy
Raman spectroscopy
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Summary:Conformational changes of heme and globin in fractionated rat erythrocytes were studied by Raman spectroscopy. Normal isoforms (common variants) of hemoglobin, which plays a key role in oxygen transport and a protective role in oxidative stress, were shown to predominate (more than 80%) in the rat blood. However, heavy-chain (3%) and light-chain (11%) isoforms, which result from protein polymerization or degradation, perform important roles in the body because by functioning in signal transmission and binding exogenous ligands.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350923010207