Pathogenetic Mechanisms of Burn Pathology Associated with Oxidative Membrane Damage and Methods of their Correction

Despite significant progress in the treatment of burn pathology, mortality in this pathology can exceed 50% when more than 30% of the body area is affected due to the development of multiple organ dysfunction syndrome. This review examines the most important molecular biological mechanisms of the de...

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Bibliographic Details
Published in:Biophysics (Oxford) 2023-02, Vol.68 (1), p.129-136
Main Authors: Vilyanen, D. V., Pashkevich, N. I., Borisova-Mubarakshina, M. M., Osochuk, S. S.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Free radicals
Inflammation
Lipid metabolism
Medical Biophysics
Mitochondrial DNA
Oxidative stress
Pathology
Physics
Physics and Astronomy
Plasma membranes
Secondary production
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Summary:Despite significant progress in the treatment of burn pathology, mortality in this pathology can exceed 50% when more than 30% of the body area is affected due to the development of multiple organ dysfunction syndrome. This review examines the most important molecular biological mechanisms of the development of multiple organ dysfunction syndrome via free radical destruction of plasma membranes, mitochondria, secondary production of free radicals by damaged mitochondria, modification of mitochondrial DNA and its use as a trigger of inflammatory processes in peripheral organs and systems. Secondary changes in the blood lipid transport system and their role in the generalization of multiple organ dysfunction and hormonal imbalance are considered. The use of antioxidants, in particular quinones, in combination with lipid metabolism modulators to reduce the activity of the inflammatory process and hormonal imbalance in the treatment of burn pathology is justified from the perspective of pathogenetic shifts in metabolism.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350923010190