Fabrication of anti-inflammatory nano eye-drops composed of dexamethasone prodrugs

Drug molecules cannot suitably permeate the cornea, but nano eye-drops may be used to improve intraocular drug permeation. We synthesized a homodimeric prodrug of dexamethasone in an anti-inflammatory drug with carbon chain linkers of varying lengths to establish a new prodrug and fabricated the cor...

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Bibliographic Details
Published in:Molecular Crystals and Liquid Crystals 2023-09, Vol.762 (1), p.81-87
Main Authors: Tanita, Keita, Iijima, Mai, Koseki, Yoshitaka, Sato, Kota, Nakazawa, Toru, Kasai, Hitoshi
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Carbon
Cornea
Dexamethasone
dexamethasone (DEX)
Drug delivery system
Fabrication
Molecular chains
nano eye-drops
Nanoparticles
Permeation
reprecipitation method
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Summary:Drug molecules cannot suitably permeate the cornea, but nano eye-drops may be used to improve intraocular drug permeation. We synthesized a homodimeric prodrug of dexamethasone in an anti-inflammatory drug with carbon chain linkers of varying lengths to establish a new prodrug and fabricated the corresponding dexamethasone nanoparticles. A longer carbon chain linker reduces the size of the nanoparticles and increases their hydrolysis resistance. The fabricated nanoparticles permeate into rat eye and then hydrolyze to release the drug. Thus, nano eye-drops seem to be a promising solution for the development of anti-inflammatory drugs with high intraocular permeation.
ISSN:1542-1406
1563-5287
1527-1943
DOI:10.1080/15421406.2023.2180212