Effect of Alginate Fabric Dressing with Silver Nanoparticles on the Course of Wound Process in Laboratory Animals

Alginates varying in modifying additives (primarily, chitosan) and physical treatment methods are used to design prototypes of innovative wound dressings. The aims of the study were to create a prototype sodium alginate fabric wound dressing with silver nanoparticles (AgNPs) subjected to ten freeze–...

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Bibliographic Details
Published in:Biophysics (Oxford) 2023-04, Vol.68 (2), p.295-301
Main Authors: Malyshko, V. V., Fedulova, L. V., Sokolov, M. E., Moiseev, A. V., Basov, A. A., Dorohova, A. A., Shashkov, D. I., Dzhimak, S. S.
Format: Article
Language:English
Subjects:
Alginic acid
Antibacterial activity
Biological and Medical Physics
Biophysics
Chitosan
Complex Systems Biophysics
Freeze-thawing
Laboratory animals
Medical dressings
Nanoparticles
Physics
Physics and Astronomy
Silver
Sodium alginate
Wounding
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Summary:Alginates varying in modifying additives (primarily, chitosan) and physical treatment methods are used to design prototypes of innovative wound dressings. The aims of the study were to create a prototype sodium alginate fabric wound dressing with silver nanoparticles (AgNPs) subjected to ten freeze–thaw cycles, to assess its properties, and to evaluate its efficacy in treating the purulent wound process in rats. The original technology of ten freeze–thaw cycles was shown to significantly increase the AgNP amount in the sodium alginate wound dressing, primarily by increasing the amount of AgNPs no larger than 15 nm in diameter, which exert the highest antibacterial activity. The wound dressing with AgNPs reduced the metabolic disturbances in the local function of the nonspecific defense system. On days 3 and 5 after wounding, free radical oxidation indices were more favorable and the levels of antioxidant enzymes (catalase and superoxide dismutase (SOD)) in wound tissue were lower than observed upon application of a wound dressing with AgNPs, but without alginate, or after daily wound debridement without using alginate or AgNPs.
ISSN:0006-3509
1555-6654
DOI:10.1134/S000635092302015X