Effect of N-Acetylcysteine on Cu2+(Fe2+)/H2O2-Mediated Free-Radical Fragmentation of Glycerophosphate in the Presence of Biologically Active Compounds

The effect of N -acetylcysteine on homolytic fragmentation of β-glycerophosphate with cleavage of the phosphoester bond has been studied. It has been shown that N -acetylcysteine activates the fragmentation induced by Cu 2+ (Fe 2+ )–H 2 O 2 and inhibits the radiation-induced process. The stimulating...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-07, Vol.93 (7), p.1711-1720
Main Authors: Ovsyannikova, E. M., Soloninkina, I. O., Yurkova, I. L.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Fragmentation
Glycerophosphate
Hydrogen peroxide
Radiation effects
Sodium azides
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Summary:The effect of N -acetylcysteine on homolytic fragmentation of β-glycerophosphate with cleavage of the phosphoester bond has been studied. It has been shown that N -acetylcysteine activates the fragmentation induced by Cu 2+ (Fe 2+ )–H 2 O 2 and inhibits the radiation-induced process. The stimulating effect of N -acetylcysteine towards Cu 2+ /H 2 O 2 -mediated fragmentation in the presence of compounds affecting the HO • level, the Cu 2+ /Cu + ratio, or interacting with thiol is either enhanced (Trolox, Ubiquinone Q 0 ) or switched to the protective one (NaN 3 , Met, ascorbate). In the presence of Fe 2+ , Trolox, unlike Q 0 , has reduced the stimulating effect of N -acetylcysteine.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223070113