Design, Synthesis, Characterization, and Biological Evaluation of Some 4-Thiazolidinone Derivatives Containing Furan and 1,2,4-Triazole Moiety

An entirely new family of 5-benzylidene-2-(furan-2-yl)-3-(4 H -1,2,4-triazol-4-yl)thiazolidin-4-ones was synthesized. Their antibacterial and antifungal activity was evaluated towards gram-positive and gram-negative strains of bacteria and fungi. Against bacterial strains, products with nitro, methy...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-07, Vol.93 (7), p.1852-1858
Main Authors: Godhani, D. R., Mehta, U. P., Mehta, J. P., Saiyad, A. H.
Format: Article
Language:English
Subjects:
Antibacterial agents
Bacteria
Benzene
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug resistance
Fungicides
Furans
Triazoles
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Summary:An entirely new family of 5-benzylidene-2-(furan-2-yl)-3-(4 H -1,2,4-triazol-4-yl)thiazolidin-4-ones was synthesized. Their antibacterial and antifungal activity was evaluated towards gram-positive and gram-negative strains of bacteria and fungi. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p -position of the benzene ring, as well as products with the nitro group at the m -position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p -position and m -position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum .
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322307023X