Conservative Protein RCC1 Is a New Component of Black Bands of Drosophilamelanogaster Polytene Chromosomes

Previously, the RCC1 gene ( Regulator of Chromosome Condensation 1 ), which is considered a regulator of chromosome condensation in the cell cycle, was characterized. This gene encodes a nuclear protein whose amino acid sequence is highly conserved among all eukaryotes and consists of seven repeatin...

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Bibliographic Details
Published in:Russian journal of developmental biology 2023, Vol.54 (2), p.160-163
Main Authors: Zykova, T. Yu, Maltseva, M. V., Demakov, S. A., Pokholkova, G. V., Veryaskina, Yu. A., Lavrik, O. I., Kolesnikova, T. D., Zhimulev, I. F.
Format: Article
Language:English
Subjects:
Amino acid sequence
Animal Anatomy
Antibodies
Biomedical and Life Sciences
Brief Communications
Cell cycle
Conserved sequence
Developmental Biology
Drosophila
Histology
Life Sciences
Morphology
Polytene
Polytene chromosomes
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Summary:Previously, the RCC1 gene ( Regulator of Chromosome Condensation 1 ), which is considered a regulator of chromosome condensation in the cell cycle, was characterized. This gene encodes a nuclear protein whose amino acid sequence is highly conserved among all eukaryotes and consists of seven repeating units. The authors have shown that all the most prominent black bands of polytene chromosomes (260 bands) and the chromocenter bind antibodies to this protein. Antibodies to the xenopus RCC1 protein specifically bind to the Drosophila and human RCC1 protein, while the relative amount of the RCC1 protein increases in Drosophila lines with under-replication suppression compared to the wild type.
ISSN:1062-3604
1608-3326
DOI:10.1134/S1062360423020078