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Role of cyanuric chloride in organic synthesis: A concise overview

Cyanuric chloride, a chlorinated analog of 1,3,5‐triazine, is used as a catalyst, promoter, and activator to catalyze and initiate several reactions like Beckmann rearrangement, Lossen rearrangement, Biginelli reaction, Suzuki coupling reaction, Pictet Spengler reaction, Mannich reaction, etc. It is...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2023-09, Vol.60 (9), p.1495-1516
Main Authors: Sethiya, Ayushi, Jangid, Dinesh K., Pradhan, Joohee, Agarwal, Shikha
Format: Article
Language:English
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Summary:Cyanuric chloride, a chlorinated analog of 1,3,5‐triazine, is used as a catalyst, promoter, and activator to catalyze and initiate several reactions like Beckmann rearrangement, Lossen rearrangement, Biginelli reaction, Suzuki coupling reaction, Pictet Spengler reaction, Mannich reaction, etc. It is employed in several reactions due to its several properties like stable, non‐volatile, cost‐efficient, easy to handle, and easy commercial availability. Moreover, it is a very renowned precursor for the synthesis of triazine‐class pesticide atrazine, dyes, and crosslinking agents. Herein in this review article, the reactions initiated, catalyzed, and promoted by cyanuric chloride from 2010 to 2022 have been elaborated. Cyanuric chloride assisted synthesis of different heterocycles.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4661