BIO-ELECTRICAL MARKERS OF CARDIAC FUNCTION FOR DONOR HEARTS ON NORMOTHERMIC MACHINE PERFUSION

Objectives: Normothermic ex-situ heart perfusion (ESHP) enables qualitative assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present ele...

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Bibliographic Details
Published in:International journal of artificial organs 2023-07, Vol.46 (7), p.430
Main Authors: Amesz, J H, Bierhuizen, M F, Langmuur, S J, Knops, P, Van Steenis, Y P, Dumay, D, Manintveld, OC, De Groot, N M, Taverne, Y J
Format: Article
Language:English
Subjects:
Abattoirs
Bioelectricity
Cardiac function
Correlation
Decision making
Electric potential
Heart
Ischemia
Lactic acid
Mapping
Muscle contraction
Parameter sensitivity
Perfusion
Reperfusion
Transplantation
Trends
Ventricle
Visual observation
Voltage
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Summary:Objectives: Normothermic ex-situ heart perfusion (ESHP) enables qualitative assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present electrophysiological (EP) parameters from electrical mapping as novel bio-electrical markers of post-ischemic cardiac performance. Methods: Porcine slaughterhouse hearts (PSH) were divided in two groups based on duration of warm ischemic time (WIT) (short WIT (
ISSN:0391-3988
1724-6040