BIO-ELECTRICAL MARKERS OF CARDIAC FUNCTION FOR DONOR HEARTS ON NORMOTHERMIC MACHINE PERFUSION

Objectives: Normothermic ex-situ heart perfusion (ESHP) enables qualitative assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present ele...

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Published in:International journal of artificial organs 2023-07, Vol.46 (7), p.430
Main Authors: Amesz, J H, Bierhuizen, M F, Langmuur, S J, Knops, P, Van Steenis, Y P, Dumay, D, Manintveld, OC, De Groot, N M, Taverne, Y J
Format: Article
Language:English
Subjects:
Abattoirs
Bioelectricity
Cardiac function
Correlation
Decision making
Electric potential
Heart
Ischemia
Lactic acid
Mapping
Muscle contraction
Parameter sensitivity
Perfusion
Reperfusion
Transplantation
Trends
Ventricle
Visual observation
Voltage
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container_issue 7
container_start_page 430
container_title International journal of artificial organs
container_volume 46
creator Amesz, J H
Bierhuizen, M F
Langmuur, S J
Knops, P
Van Steenis, Y P
Dumay, D
Manintveld, OC
De Groot, N M
Taverne, Y J
description Objectives: Normothermic ex-situ heart perfusion (ESHP) enables qualitative assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present electrophysiological (EP) parameters from electrical mapping as novel bio-electrical markers of post-ischemic cardiac performance. Methods: Porcine slaughterhouse hearts (PSH) were divided in two groups based on duration of warm ischemic time (WIT) (short WIT (
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However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present electrophysiological (EP) parameters from electrical mapping as novel bio-electrical markers of post-ischemic cardiac performance. Methods: Porcine slaughterhouse hearts (PSH) were divided in two groups based on duration of warm ischemic time (WIT) (short WIT (&lt;5 min.) vs. long WIT (ca. 10 min.). Hearts were instrumented on a Langendorff-perfusion device and electrical mapping of the right (RV) and left ventricle (LV) was performed 60 minutes after start of reperfusion. EP parameters including potential voltages, slopes and conduction velocities were calculated from these measurements and correlated to lactate trends and visual contractile performance of the PSH. Results: Unipolar voltages were lower in the long WIT group compared to the short WIT group (RV: 3.8 vs. 16.4 mV, p=0.057. LV: 10.8 vs. 23.6 mV, p=0.029). In addition, more low-voltage, lower potential slopes, slower conduction velocities and more conduction block was found in the LWIT group. Unipolar voltages and potential slopes of the RV strongly correlated with the visual contractile performance of the PSH. In addition, less correlation was observed between these EP parameters and lactate trends. Conclusions: Prolonged WIT was associated with lower potential voltages, decreased potential slopes and slower conduction in a porcine DCD model and unipolar voltage appeared the strongest marker of cardiac performance. These bio-electrical markers can hopefully aid transplantation teams in decision-making on transplantability of DCD hearts on ESHP.</description><identifier>ISSN: 0391-3988</identifier><identifier>EISSN: 1724-6040</identifier><language>eng</language><publisher>Milan: Wichtig Editore s.r.l</publisher><subject>Abattoirs ; Bioelectricity ; Cardiac function ; Correlation ; Decision making ; Electric potential ; Heart ; Ischemia ; Lactic acid ; Mapping ; Muscle contraction ; Parameter sensitivity ; Perfusion ; Reperfusion ; Transplantation ; Trends ; Ventricle ; Visual observation ; Voltage</subject><ispartof>International journal of artificial organs, 2023-07, Vol.46 (7), p.430</ispartof><rights>Copyright Wichtig Editore s.r.l. Jul 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Amesz, J H</creatorcontrib><creatorcontrib>Bierhuizen, M F</creatorcontrib><creatorcontrib>Langmuur, S J</creatorcontrib><creatorcontrib>Knops, P</creatorcontrib><creatorcontrib>Van Steenis, Y P</creatorcontrib><creatorcontrib>Dumay, D</creatorcontrib><creatorcontrib>Manintveld, OC</creatorcontrib><creatorcontrib>De Groot, N M</creatorcontrib><creatorcontrib>Taverne, Y J</creatorcontrib><title>BIO-ELECTRICAL MARKERS OF CARDIAC FUNCTION FOR DONOR HEARTS ON NORMOTHERMIC MACHINE PERFUSION</title><title>International journal of artificial organs</title><description>Objectives: Normothermic ex-situ heart perfusion (ESHP) enables qualitative assessment of hearts donated after circulatory death (DCD) prior to transplantation. However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present electrophysiological (EP) parameters from electrical mapping as novel bio-electrical markers of post-ischemic cardiac performance. Methods: Porcine slaughterhouse hearts (PSH) were divided in two groups based on duration of warm ischemic time (WIT) (short WIT (&lt;5 min.) vs. long WIT (ca. 10 min.). Hearts were instrumented on a Langendorff-perfusion device and electrical mapping of the right (RV) and left ventricle (LV) was performed 60 minutes after start of reperfusion. EP parameters including potential voltages, slopes and conduction velocities were calculated from these measurements and correlated to lactate trends and visual contractile performance of the PSH. Results: Unipolar voltages were lower in the long WIT group compared to the short WIT group (RV: 3.8 vs. 16.4 mV, p=0.057. LV: 10.8 vs. 23.6 mV, p=0.029). In addition, more low-voltage, lower potential slopes, slower conduction velocities and more conduction block was found in the LWIT group. Unipolar voltages and potential slopes of the RV strongly correlated with the visual contractile performance of the PSH. In addition, less correlation was observed between these EP parameters and lactate trends. Conclusions: Prolonged WIT was associated with lower potential voltages, decreased potential slopes and slower conduction in a porcine DCD model and unipolar voltage appeared the strongest marker of cardiac performance. These bio-electrical markers can hopefully aid transplantation teams in decision-making on transplantability of DCD hearts on ESHP.</description><subject>Abattoirs</subject><subject>Bioelectricity</subject><subject>Cardiac function</subject><subject>Correlation</subject><subject>Decision making</subject><subject>Electric potential</subject><subject>Heart</subject><subject>Ischemia</subject><subject>Lactic acid</subject><subject>Mapping</subject><subject>Muscle contraction</subject><subject>Parameter sensitivity</subject><subject>Perfusion</subject><subject>Reperfusion</subject><subject>Transplantation</subject><subject>Trends</subject><subject>Ventricle</subject><subject>Visual observation</subject><subject>Voltage</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqNi70OwiAAhInRxPrzDiTOJFBqbUekEIgtGEpH0zjUoTFWW31_GXwAl7tc7vtmICKHOEEpTvAcRJjmBNE8y5ZgNU09xiRNkn0ELkdtkSgF905zVsKKuZNwNbQScuYKzTiUjeFeWwOldbCwJqQSzPkAGRhWZb0SrtI8yFxpI-BZONnUQdmAxe16n7rtr9dgJ4XnCj3H4fXppnfbD5_xEa42zlKcUUJTQv-jvg2iO70</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Amesz, J H</creator><creator>Bierhuizen, M F</creator><creator>Langmuur, S J</creator><creator>Knops, P</creator><creator>Van Steenis, Y P</creator><creator>Dumay, D</creator><creator>Manintveld, OC</creator><creator>De Groot, N M</creator><creator>Taverne, Y J</creator><general>Wichtig Editore s.r.l</general><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>20230701</creationdate><title>BIO-ELECTRICAL MARKERS OF CARDIAC FUNCTION FOR DONOR HEARTS ON NORMOTHERMIC MACHINE PERFUSION</title><author>Amesz, J H ; 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However, additional and sensitive parameters of cardiac function of DCD hearts on ESHP are needed. The aim of this study was to present electrophysiological (EP) parameters from electrical mapping as novel bio-electrical markers of post-ischemic cardiac performance. Methods: Porcine slaughterhouse hearts (PSH) were divided in two groups based on duration of warm ischemic time (WIT) (short WIT (&lt;5 min.) vs. long WIT (ca. 10 min.). Hearts were instrumented on a Langendorff-perfusion device and electrical mapping of the right (RV) and left ventricle (LV) was performed 60 minutes after start of reperfusion. EP parameters including potential voltages, slopes and conduction velocities were calculated from these measurements and correlated to lactate trends and visual contractile performance of the PSH. Results: Unipolar voltages were lower in the long WIT group compared to the short WIT group (RV: 3.8 vs. 16.4 mV, p=0.057. LV: 10.8 vs. 23.6 mV, p=0.029). 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subjects Abattoirs
Bioelectricity
Cardiac function
Correlation
Decision making
Electric potential
Heart
Ischemia
Lactic acid
Mapping
Muscle contraction
Parameter sensitivity
Perfusion
Reperfusion
Transplantation
Trends
Ventricle
Visual observation
Voltage
title BIO-ELECTRICAL MARKERS OF CARDIAC FUNCTION FOR DONOR HEARTS ON NORMOTHERMIC MACHINE PERFUSION
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