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Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects
The association of the rs1344706 polymorphism of the ZNF804A gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders ( n = 93) and me...
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| Published in: | Neuroscience and behavioral physiology 2023-06, Vol.53 (5), p.846-855 |
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| container_end_page | 855 |
| container_issue | 5 |
| container_start_page | 846 |
| container_title | Neuroscience and behavioral physiology |
| container_volume | 53 |
| creator | Garakh, Zh. V. Golimbet, V. E. Larionova, E. V. Lezheiko, T. V. Strelets, V. B. Zaytseva, Yu. S. |
| description | The association of the rs1344706 polymorphism of the
ZNF804A
gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders (
n
= 93) and mentally healthy subjects (
n
= 93). On reading verbal information, regardless of mental status, subjects with the AA genotype showed lower synchronization of the θ rhythm than carriers of the C allele. As compared with carriers of the C allele, healthy carriers of the AA allele showed lower synchronization of the θ rhythm in the posterior cortical areas of the left hemisphere, no difference in synchronization of the γ rhythm, and desynchronization of the μ rhythm on perception of semantic and meaningless verbal information. Patients carrying the AA variant, as compared with carriers of the C variant, showed a lower degree of μ-rhythm desynchronization, which correlated with the severity of speech disorders on the PANSS. The results obtained here indicate that the rs1344706 polymorphism of the
ZNF804A
gene has a modulating effect on the neurophysiological characteristics of the reading process and contributes to the variability of clinically expressed speech disorders. |
| doi_str_mv | 10.1007/s11055-023-01477-7 |
| format | article |
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ZNF804A
gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders (
n
= 93) and mentally healthy subjects (
n
= 93). On reading verbal information, regardless of mental status, subjects with the AA genotype showed lower synchronization of the θ rhythm than carriers of the C allele. As compared with carriers of the C allele, healthy carriers of the AA allele showed lower synchronization of the θ rhythm in the posterior cortical areas of the left hemisphere, no difference in synchronization of the γ rhythm, and desynchronization of the μ rhythm on perception of semantic and meaningless verbal information. Patients carrying the AA variant, as compared with carriers of the C variant, showed a lower degree of μ-rhythm desynchronization, which correlated with the severity of speech disorders on the PANSS. The results obtained here indicate that the rs1344706 polymorphism of the
ZNF804A
gene has a modulating effect on the neurophysiological characteristics of the reading process and contributes to the variability of clinically expressed speech disorders.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/s11055-023-01477-7</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Alleles ; Behavioral Sciences ; Biomedical and Life Sciences ; Biomedicine ; EEG ; Gene polymorphism ; Hemispheric laterality ; Language ; Mental disorders ; Neurobiology ; Neurosciences ; Polymorphism ; Schizophrenia ; Semantics ; Speech ; Speech disorders ; Speech perception ; Synchronization ; Visual perception ; Visual stimuli</subject><ispartof>Neuroscience and behavioral physiology, 2023-06, Vol.53 (5), p.846-855</ispartof><rights>Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2347-68b0799caa6411c9853ff85b872f230a545f93fa3ddafe5d812ac423379daca43</citedby><cites>FETCH-LOGICAL-c2347-68b0799caa6411c9853ff85b872f230a545f93fa3ddafe5d812ac423379daca43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Garakh, Zh. V.</creatorcontrib><creatorcontrib>Golimbet, V. E.</creatorcontrib><creatorcontrib>Larionova, E. V.</creatorcontrib><creatorcontrib>Lezheiko, T. V.</creatorcontrib><creatorcontrib>Strelets, V. B.</creatorcontrib><creatorcontrib>Zaytseva, Yu. S.</creatorcontrib><title>Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physi</addtitle><description>The association of the rs1344706 polymorphism of the
ZNF804A
gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders (
n
= 93) and mentally healthy subjects (
n
= 93). On reading verbal information, regardless of mental status, subjects with the AA genotype showed lower synchronization of the θ rhythm than carriers of the C allele. As compared with carriers of the C allele, healthy carriers of the AA allele showed lower synchronization of the θ rhythm in the posterior cortical areas of the left hemisphere, no difference in synchronization of the γ rhythm, and desynchronization of the μ rhythm on perception of semantic and meaningless verbal information. Patients carrying the AA variant, as compared with carriers of the C variant, showed a lower degree of μ-rhythm desynchronization, which correlated with the severity of speech disorders on the PANSS. The results obtained here indicate that the rs1344706 polymorphism of the
ZNF804A
gene has a modulating effect on the neurophysiological characteristics of the reading process and contributes to the variability of clinically expressed speech disorders.</description><subject>Alleles</subject><subject>Behavioral Sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>EEG</subject><subject>Gene polymorphism</subject><subject>Hemispheric laterality</subject><subject>Language</subject><subject>Mental disorders</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Polymorphism</subject><subject>Schizophrenia</subject><subject>Semantics</subject><subject>Speech</subject><subject>Speech disorders</subject><subject>Speech perception</subject><subject>Synchronization</subject><subject>Visual perception</subject><subject>Visual stimuli</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1qGzEUhUVpoW7SF-hK0PW0-rWkpTGOEwhtqJsQuhGyRopkZqSpNENwH6rP2End0F1WF-493zlwDwAfMPqEERKfK8aI8wYR2iDMhGjEK7DAXNBGKnX_GiwQUqJBnKm34F2tBzRDQqIF-L2qNdtoxpgTzB6OwcFSMWVMoCW8yd2xz2UIsfbP1x9fLiRiK7h1ycHHOAZ4ldrJuhZuNlv4LRzH0MN1MOnBVdhOJaYHeBfrZDp444p1w3PUnSv7ebkbYz91EcYEL53pxnCEJrVwZ0P8lYdQXIoW7qb9wdmxnoM33nTVvf83z8Dtxeb7-rK5_rq9Wq-uG0soE81S7pFQyhqzZBhbJTn1XvK9FMQTigxn3CvqDW1b4x1vJSbGMkKpUK2xhtEz8PHkO5T8c3J11Ic8lTRHaiKXGBGOGJ5V5KSyJddanNdDib0pR42RfupFn3rRcy_6by9azBA9QXV4-o0r_61foP4AwIqQ3g</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Garakh, Zh. 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V. ; Golimbet, V. E. ; Larionova, E. V. ; Lezheiko, T. V. ; Strelets, V. B. ; Zaytseva, Yu. 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V.</au><au>Golimbet, V. E.</au><au>Larionova, E. V.</au><au>Lezheiko, T. V.</au><au>Strelets, V. B.</au><au>Zaytseva, Yu. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><stitle>Neurosci Behav Physi</stitle><date>2023-06-01</date><risdate>2023</risdate><volume>53</volume><issue>5</issue><spage>846</spage><epage>855</epage><pages>846-855</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>The association of the rs1344706 polymorphism of the
ZNF804A
gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders (
n
= 93) and mentally healthy subjects (
n
= 93). On reading verbal information, regardless of mental status, subjects with the AA genotype showed lower synchronization of the θ rhythm than carriers of the C allele. As compared with carriers of the C allele, healthy carriers of the AA allele showed lower synchronization of the θ rhythm in the posterior cortical areas of the left hemisphere, no difference in synchronization of the γ rhythm, and desynchronization of the μ rhythm on perception of semantic and meaningless verbal information. Patients carrying the AA variant, as compared with carriers of the C variant, showed a lower degree of μ-rhythm desynchronization, which correlated with the severity of speech disorders on the PANSS. The results obtained here indicate that the rs1344706 polymorphism of the
ZNF804A
gene has a modulating effect on the neurophysiological characteristics of the reading process and contributes to the variability of clinically expressed speech disorders.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11055-023-01477-7</doi><tpages>10</tpages></addata></record> |
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| subjects | Alleles Behavioral Sciences Biomedical and Life Sciences Biomedicine EEG Gene polymorphism Hemispheric laterality Language Mental disorders Neurobiology Neurosciences Polymorphism Schizophrenia Semantics Speech Speech disorders Speech perception Synchronization Visual perception Visual stimuli |
| title | Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects |
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