Ultrasound-based surface sampling in immersion for mass spectrometry

We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample dis...

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Bibliographic Details
Published in:Journal of applied physics 2023-09, Vol.134 (10)
Main Authors: Sillanpää, Tom, Hyvönen, Jere, Mäkinen, Joni, Holmström, Axi, Pudas, Topi, Lassila, Petri, Lepistö, Riikka, Kuronen, Antti, Kotiaho, Tapio, Hæggström, Edward, Salmi, Ari
Format: Article
Language:English
Subjects:
Cavitation
Chemical analysis
Mass spectrometry
Sampling methods
Submerging
Transducers
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Summary:We present a surface sampling method for the chemical analysis of liquid-immersed solid samples. Liquid immersion allows samples to be kept in a hydrated state. We employed cavitation generated by high-intensity focused ultrasound for localized material removal. The appropriate transducer–sample distance was determined using the actuating ultrasound transducer prior to sampling, allowing sonication in focus despite surface height variation. We demonstrate the proposed surface sampling method on water-submerged glass cover slides painted with permanent markers, achieving sampling with tunable spot size down to 500  μm. The removed and collected material was transferred for chemical analysis by electrospray ionization mass spectrometry, which showed mass peaks characteristic to the permanent markers.
ISSN:0021-8979
1089-7550
DOI:10.1063/5.0157705