Nobiletin as a chemopreventive natural product against cancer, a comprehensive review

As a leading cause of death, second only to heart disease, cancer has always been one of the burning topics in medical research. When targeting multiple signal pathways in tumorigenesis chemoprevention, using natural or synthetic anti-cancer drugs is a vital strategy to reduce cancer damage. However...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2023-09, Vol.63 (23), p.6309-6329
Main Authors: Chen, Yun-Yi, Liang, Jiao-Jiao, Wang, Deng-Liang, Chen, Jie-Biao, Cao, Jin-Ping, Wang, Yue, Sun, Chong-De
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic drugs
Antitumor agents
Biocompatibility
Biological activity
Biological effects
Cancer
Cardiovascular diseases
chemoprevention
Citrus fruits
Drug development
Drugs
Flavonoids
Heart diseases
In vivo methods and tests
mechanism
Medical research
Multidrug resistance
Natural products
nobiletin
Reviews
Side effects
Stem cells
Tumorigenesis
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Summary:As a leading cause of death, second only to heart disease, cancer has always been one of the burning topics in medical research. When targeting multiple signal pathways in tumorigenesis chemoprevention, using natural or synthetic anti-cancer drugs is a vital strategy to reduce cancer damage. However, toxic effects, multidrug resistance (MDR) as well as cancer stem cells (CSCs) all prominently limited the clinical application of conventional anticancer drugs. With low side effects, strong biological activity, unique mechanism, and wide range of targets, natural products derived from plants are considered significant sources for new drug development. Nobiletin is one of the most attractive compounds, a unique flavonoid primarily isolated from the peel of citrus fruits. Numerous studies in vitro and in vivo have suggested that nobiletin and its derivatives possess the eminent potential to become effective cancer chemoprevention agents through various cellular and molecular levels. This article aims to comprehensively review the anticancer efficacy and specific mechanisms of nobiletin, enhancing our understanding of its chemoprevention properties and providing the latest research findings. At the end of this review, we also give some discussion and future perspectives regarding the challenges and opportunities in nobiletin efficient exploitation.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2022.2030297