Loading…
A convenient synthesis of methyl 4-oxo-4,5-dihydropyrazolo[1,5-a]-pyrazine-7-carboxylates and corresponding carboxylic acids
Pyrazolo[1,5- a ]pyrazin-4(5 H )-ones react regioselectively with N -iodosuccinimide in the presence of N -methylmorpholine to form 7-iodo derivatives. Their carbonylation catalyzed with Pd(dppf)Cl2 under pressure in MeOH solution yielded methyl 4-oxo-4,5-dihydropyrazolo-[1,5- a ]pyrazine-7-carboxyl...
Saved in:
Published in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2023-07, Vol.59 (6-7), p.425-428 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Pyrazolo[1,5-
a
]pyrazin-4(5
H
)-ones react regioselectively with
N
-iodosuccinimide in the presence of
N
-methylmorpholine to form 7-iodo derivatives. Their carbonylation catalyzed with Pd(dppf)Cl2 under pressure in MeOH solution yielded methyl 4-oxo-4,5-dihydropyrazolo-[1,5-
a
]pyrazine-7-carboxylates, which were transformed into the corresponding carboxylic acids by alkaline hydrolysis. |
---|---|
ISSN: | 0009-3122 1573-8353 |
DOI: | 10.1007/s10593-023-03212-z |